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Antiviral activity against EBV infected in P3HR1 cells assessed as decrease in viral replication
Assay data:6 Active, 1 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity to EpsteinBarr virus Transmembrane domain 5 of latent membrane protein 1 assessed as dissociation constant by spectrofluorimetric analysis
Assay data:3 Active, 5 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of recombinant EpsteinBarr virus Transmembrane domain 5 of latent membrane protein 1 transformed into Escherichia coli FHK12 cells assessed as disruption of oligomerization by measuring ToxR transcription activity assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 6 Tested
Reactivation of latent EBV infected in human MUTU-I cells incubated for 48 hrs by steady-glo luciferase reporter assay
Assay data:18 Active, 11 Activity ≤ 1 µM, 18 Tested
Antiviral activity against Epstein-Barr virus
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Antiviral activity against EBV infected in human Raji cells assessed as reduction in viral genome copy numbers by qRT-PCR analysis
Assay data:1 Active, 2 Tested
Displacement of TO from EB virus g4-EBNA1 mRNA measured after 5 mins by FID assay
Assay data:18 Active, 15 Activity ≤ 1 µM, 21 Tested
Antiviral activity against EBV infected in human AKATA cells assessed as reduction in IgG-induced lytic virus replication measured at 48 hrs post-lytic induction by qRT-PCR analysis
Assay data:2 Active, 6 Tested
Inhibition of Epstein-Barr virus-induced human B95-8 cell proliferation after 72 hrs by MTT assay
Inhibition of Epstein-Barr virus-induced human Raji cell proliferation after 72 hrs by MTT assay
Inhibition of Epstein-Barr virus-induced human Daudi cell proliferation after 72 hrs by MTT assay
Inhibition of recombinant EBNA1 binding to biotin-labeled Epstein-Barr virus OriP hairpin DNA EBNA1 site 2 mutant assessed as dissociation constant by SPR assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of recombinant EBNA1 binding to biotin-labeled Epstein-Barr virus OriP hairpin DNA EBNA1 site 2 assessed as dissociation constant by SPR assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of recombinant EBNA1 binding to biotin-labeled Epstein-Barr virus OriP hairpin DNA EBNA1 site 1 mutant assessed as dissociation constant by SPR assay
Inhibition of recombinant EBNA1 binding to biotin-labeled Epstein-Barr virus OriP hairpin DNA EBNA1 site 1 assessed as dissociation constant by SPR assay
Inhibition of TPA/sodium butyrate-induced EBV lytic DNA replication in human P3HR1 cells incubated for 48 hrs post TPA/sodium butyrate induction by real-time PCR method
Assay data:22 Active, 3 Activity ≤ 1 µM, 25 Tested
Inhibition of TPA-induced EBV-early antigen activation in human Raji cells after 48 hrs by indirect immunofluorescence method
Assay data:8 Active, 11 Tested
Antiviral activity against EBV infected in TPA and sodium butyrate-induced P3HR1 cells assessed as inhibition on EBV lytic replication incubated for 48 hrs by SYBR green dye based real-time PCR method
Assay data:6 Active, 12 Tested
Antiviral activity against EBV infected in human Akata cells by DNA hybridization assay
Assay data:2 Tested
SummaryPubMed Citation
Antiviral activity against EBV infected in human P3HR1 cells assessed as inhibition of lytic viral DNA replication after 48 hrs by RT-PCR analysis
Assay data:8 Active, 28 Tested
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